Cagrilintide vs Retatrutide
Which should you choose? Here's what you need to know.
The short answer
Retatrutide is a triple agonist (GLP-1/GIP/glucagon) with the highest weight loss ever seen in trials. Cagrilintide works through the amylin system — different mechanism, less nausea, but usually combined with semaglutide as CagriSema.
On 9 Oct 2026 Peptide Compare tracked 38 vendors selling Cagrilintide, cheapest in stock $4.50 per mg at Amino Sequence, and 31 selling Retatrutide, cheapest $2.20 per mg at Modern Research.
Cagrilintide
Weight Loss (GLP-1)Cagrilintide is a long-acting amylin receptor agonist that suppresses appetite through satiety signaling. On its own it produces moderate weight loss, but combined with semaglutide as CagriSema it achieved 20.4% weight loss in Phase 3.
Choose Cagrilintide if:
You want a different mechanism from GLP-1 agonists, experience less nausea, or are interested in CagriSema's combination approach.
Retatrutide
Weight Loss (GLP-1)Retatrutide is a first-in-class triple agonist hitting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 trials showed 28.7% mean body weight loss — the most ever reported for any obesity drug.
Choose Retatrutide if:
You want the most aggressive weight loss possible and are comfortable with a peptide still in clinical trials.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Oct 9, 2026.
Cagrilintide
Retatrutide
$32.58
Starting from
$25.99
$16.32
Avg. price per mg
$10.03
38
Vendors selling it
31
41 options
In stock now
98 options
9.0/10
Top trust score
9.0/10
Ready to buy?
Our top-rated vendor for each, based on trust scores, purity testing, and price.
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.