Cagrilintide vs Retatrutide
Which should you choose? Here's what you need to know.
The short answer
Retatrutide is a triple agonist (GLP-1/GIP/glucagon) with the highest weight loss ever seen in trials. Cagrilintide works through the amylin system — different mechanism, less nausea, but usually combined with semaglutide as CagriSema.
Cagrilintide
Weight Loss (GLP-1)Cagrilintide is a long-acting amylin receptor agonist that suppresses appetite through satiety signaling. On its own it produces moderate weight loss, but combined with semaglutide as CagriSema it achieved 20.4% weight loss in Phase 3.
Choose Cagrilintide if:
You want a different mechanism from GLP-1 agonists, experience less nausea, or are interested in CagriSema's combination approach.
Retatrutide
Weight Loss (GLP-1)Retatrutide is a first-in-class triple agonist hitting GLP-1, GIP, and glucagon receptors simultaneously. Phase 3 trials showed 28.7% mean body weight loss — the most ever reported for any obesity drug.
Choose Retatrutide if:
You want the most aggressive weight loss possible and are comfortable with a peptide still in clinical trials.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options.
Cagrilintide
Retatrutide
$29.99
Starting from
$25.99
$16.84
Avg. price per mg
$10.61
43
Vendors selling it
40
50 options
In stock now
119 options
9.0/10
Top trust score
9.0/10
Ready to buy?
Our top-rated vendor for each, based on trust scores, purity testing, and price.
Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.