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HomePeptidesAOD-9604 vs Semaglutide

AOD-9604 vs Semaglutide

Which should you choose? Here's what you need to know.

The short answer

Semaglutide is FDA-approved with strong clinical evidence for significant weight loss. AOD-9604 is a growth hormone fragment studied for fat metabolism, but it has not shown consistent weight loss results in human trials.

AOD-9604

Weight Loss (GLP-1)

AOD-9604 is a synthetic fragment of human growth hormone (amino acids 177-191) that's been studied for its effects on fat metabolism. It's researched for stimulating fat breakdown and inhibiting fat creation without affecting blood sugar or growth.

Choose AOD-9604 if:

You want a peptide studied specifically for fat metabolism without appetite suppression, or you can't tolerate GLP-1 side effects like nausea.

Semaglutide

Weight Loss (GLP-1)

Semaglutide is the active ingredient in Ozempic and Wegovy — an FDA-approved GLP-1 receptor agonist with extensive clinical data. The STEP 1 trial showed an average of 14.9% body weight loss over 68 weeks. It works by reducing appetite, slowing digestion, and improving insulin sensitivity.

Choose Semaglutide if:

You want a clinically proven, FDA-approved option with the strongest weight loss evidence available.

Price & availability

Once you've decided which peptide fits your needs, here's how they compare on price and vendor options.

AOD-9604
Semaglutide
$25.00
Starting from
$20.00
$10.48
Avg. price per mg
$22.28
53
Vendors selling it
36
52 options
In stock now
77 options
9.1/10
Top trust score
8.7/10

Ready to buy?

Our top-rated vendor for each, based on trust scores, purity testing, and price.

Best AOD-9604 Vendor

NextGen Health
NextGen Health
7.9/10

$30.00(5mg)

Check Price

Best Semaglutide Vendor

Polaris Peptides
Polaris Peptides
7.3/10

$165.00(20mg)

Check Price
See all AOD-9604 vendorsSee all Semaglutide vendors

Where does this data come from?

We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.