Cagrilintide vs Semaglutide
Which should you choose? Here's what you need to know.
The short answer
Semaglutide is the proven GLP-1 standard (Ozempic/Wegovy). Cagrilintide works through amylin receptors — a completely different pathway. Novo Nordisk is actually combining them as CagriSema for even better results.
Cagrilintide
Weight Loss (GLP-1)Cagrilintide is a long-acting amylin analog that mimics the satiety hormone your pancreas releases after meals. It has notably lower nausea rates than GLP-1 agonists.
Choose Cagrilintide if:
You can't tolerate GLP-1 side effects like nausea, or you're specifically interested in amylin-pathway appetite suppression.
Semaglutide
Weight Loss (GLP-1)Semaglutide is the gold-standard GLP-1 receptor agonist with FDA approval for both diabetes and weight management. It has the most real-world safety data of any weight loss peptide.
Choose Semaglutide if:
You want the most proven, FDA-approved option with years of real-world data across millions of patients.
Using both together
Cagrilintide + semaglutide (CagriSema) is Novo Nordisk's next-gen combination, achieving 20.4% weight loss in Phase 3 — better than either alone. FDA filing submitted Dec 2025.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options.
Cagrilintide
Semaglutide
$29.99
Starting from
$20.00
$16.84
Avg. price per mg
$22.28
43
Vendors selling it
36
50 options
In stock now
77 options
9.0/10
Top trust score
8.7/10
Ready to buy?
Our top-rated vendor for each, based on trust scores, purity testing, and price.
Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.