FOXO4-DRI vs Humanin
Which should you choose? Here's what you need to know.
The short answer
FOXO4-DRI and Humanin are both metabolic / longevity peptides, but they work differently. A D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells. A mitochondria-derived peptide with cytoprotective properties. Studied for neuroprotection, metabolic regulation, and cellular stress response. Compare vendor pricing and availability below.
On 20 Sep 2026 Peptide Compare tracked 28 vendors selling FOXO4-DRI, cheapest in stock $3.09 per mg at AMC Essentials, and 7 selling Humanin, cheapest $12.15 per mg at Oasis Labs.
FOXO4-DRI
Metabolic / LongevityA D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells.
Humanin
Metabolic / LongevityA mitochondria-derived peptide with cytoprotective properties. Studied for neuroprotection, metabolic regulation, and cellular stress response.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Sep 20, 2026.
FOXO4-DRI
Humanin
$44.99
Starting from
$46.00
$16.95
Avg. price per mg
$11.31
28
Vendors selling it
7
23 options
In stock now
4 options
9.0/10
Top trust score
6.6/10
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.