FOXO4-DRI vs MOTS-c
Which should you choose? Here's what you need to know.
The short answer
FOXO4-DRI and MOTS-c are both metabolic / longevity peptides, but they work differently. A D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells. A mitochondria-derived peptide that regulates metabolic homeostasis. Often called an "exercise mimetic" for its effects on AMPK activation and metabolism. Compare vendor pricing and availability below.
On 20 Sep 2026 Peptide Compare tracked 28 vendors selling FOXO4-DRI, cheapest in stock $3.09 per mg at AMC Essentials, and 61 selling MOTS-c, cheapest $1.35 per mg at Step One.
FOXO4-DRI
Metabolic / LongevityA D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells.
MOTS-c
Metabolic / LongevityA mitochondria-derived peptide that regulates metabolic homeostasis. Often called an "exercise mimetic" for its effects on AMPK activation and metabolism.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Sep 20, 2026.
FOXO4-DRI
MOTS-c
$44.99
Starting from
$22.00
$16.95
Avg. price per mg
$5.40
28
Vendors selling it
61
23 options
In stock now
83 options
9.0/10
Top trust score
9.0/10
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.