Mazdutide vs Retatrutide
Which should you choose? Here's what you need to know.
The short answer
Both are next-gen dual/triple agonists showing dramatic weight loss. Retatrutide hits three receptors and has the highest weight loss data. Mazdutide is a dual agonist already approved in China.
On 20 Sep 2026 Peptide Compare tracked 11 vendors selling Mazdutide, cheapest in stock $7.00 per mg at Eros Peptides, and 33 selling Retatrutide, cheapest $1.50 per mg at Step One.
Mazdutide
Weight Loss (GLP-1)Mazdutide is a GLP-1/glucagon dual agonist developed by Innovent Biologics. It beat semaglutide in a head-to-head trial and is already approved in China. Phase 2 trials in the US are underway.
Choose Mazdutide if:
You want a dual agonist that's already approved somewhere and has head-to-head data showing superiority over semaglutide.
Retatrutide
Weight Loss (GLP-1)Retatrutide is Eli Lilly's triple agonist (GLP-1/GIP/glucagon) with 28.7% mean weight loss in Phase 3 — the highest ever recorded. It adds a GIP receptor on top of mazdutide's dual mechanism.
Choose Retatrutide if:
You want the most aggressive weight loss possible from a triple-receptor mechanism, and you're comfortable with a still-unapproved compound.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Sep 20, 2026.
Mazdutide
Retatrutide
$34.99
Starting from
$25.99
$15.28
Avg. price per mg
$9.90
11
Vendors selling it
33
9 options
In stock now
111 options
7.6/10
Top trust score
9.0/10
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.