Mazdutide vs Tirzepatide
Which should you choose? Here's what you need to know.
The short answer
Both are dual agonists but hit different receptor combinations. Tirzepatide targets GIP/GLP-1 and is FDA-approved. Mazdutide targets GLP-1/glucagon and is approved in China.
Mazdutide
Weight Loss (GLP-1)Mazdutide is a GLP-1/glucagon dual agonist that achieved ~20% weight loss in Phase 3 and beat semaglutide in a head-to-head trial. It's approved in China but still in Phase 2 in the US.
Choose Mazdutide if:
You're interested in the glucagon component for additional metabolic benefits, or you have access to mazdutide through international channels.
Tirzepatide
Weight Loss (GLP-1)Tirzepatide (Mounjaro/Zepbound) is a GIP/GLP-1 dual agonist with FDA approval and up to 22.5% weight loss in trials. It's the established market leader for dual-agonist weight loss.
Choose Tirzepatide if:
You want an FDA-approved option available now with the broadest clinical data for a dual agonist.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options.
Mazdutide
Tirzepatide
$34.99
Starting from
$26.00
$15.06
Avg. price per mg
$9.05
13
Vendors selling it
33
9 options
In stock now
96 options
7.6/10
Top trust score
9.0/10
Ready to buy?
Our top-rated vendor for each, based on trust scores, purity testing, and price.
Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.