Melanotan 2 vs PT-141
Which should you choose? Here's what you need to know.
The short answer
Melanotan II is a broad melanocortin agonist that tans skin and boosts libido as a side effect. PT-141 was derived from Melanotan II but refined to target sexual function specifically — and it's actually FDA-approved for low sexual desire.
Melanotan 2
Anti-Aging / SkinMelanotan II is a synthetic analog of alpha-MSH that activates multiple melanocortin receptors. It's primarily studied for stimulating melanin production (skin darkening), but it also causes appetite suppression and increased sexual arousal as side effects.
Choose Melanotan 2 if:
You're primarily interested in skin darkening effects and consider the libido boost a secondary benefit.
PT-141
Sexual HealthPT-141 (bremelanotide, brand name Vyleesi) is a metabolite of Melanotan II refined to target melanocortin-4 receptors involved in sexual desire. It's FDA-approved for treating hypoactive sexual desire disorder. Unlike Viagra-type drugs, it works through the central nervous system rather than blood flow.
Choose PT-141 if:
Your primary goal is addressing sexual desire or arousal, and you want the option that's specifically designed and FDA-approved for that purpose.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options.
Melanotan 2
PT-141
$15.00
Starting from
$20.00
$5.93
Avg. price per mg
$5.38
44
Vendors selling it
54
37 options
In stock now
53 options
9.1/10
Top trust score
9.0/10
Ready to buy?
Our top-rated vendor for each, based on trust scores, purity testing, and price.
Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.