AICAR vs FOXO4-DRI
Which should you choose? Here's what you need to know.
The short answer
AICAR and FOXO4-DRI are both metabolic / longevity peptides, but they work differently. A D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells. Compare vendor pricing and availability below.
On 19 Sep 2026 Peptide Compare tracked 8 vendors selling AICAR, cheapest in stock $0.760 per mg at Ruo Bio, and 28 selling FOXO4-DRI, cheapest $3.09 per mg at AMC Essentials.
AICAR
Metabolic / LongevityFOXO4-DRI
Metabolic / LongevityA D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Sep 19, 2026.
AICAR
FOXO4-DRI
$38.00
Starting from
$44.99
$1.18
Avg. price per mg
$16.95
8
Vendors selling it
28
4 options
In stock now
23 options
7.6/10
Top trust score
9.0/10
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Our top-rated vendor for each, based on trust scores, purity testing, and price.
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.