FOXO4-DRI vs SS-31
Which should you choose? Here's what you need to know.
The short answer
FOXO4-DRI and SS-31 are both metabolic / longevity peptides, but they work differently. A D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells. A mitochondria-targeted peptide (also known as Elamipretide) that stabilizes cardiolipin in the inner mitochondrial membrane. Studied for mitochondrial dysfunction. Compare vendor pricing and availability below.
On 19 Sep 2026 Peptide Compare tracked 28 vendors selling FOXO4-DRI, cheapest in stock $3.09 per mg at AMC Essentials, and 28 selling SS-31, cheapest $2.40 per mg at Aavant Research.
FOXO4-DRI
Metabolic / LongevityA D-retro-inverso peptide that disrupts the FOXO4-p53 interaction in senescent cells. Studied as a potential senolytic agent for clearing aged cells.
SS-31
Metabolic / LongevityA mitochondria-targeted peptide (also known as Elamipretide) that stabilizes cardiolipin in the inner mitochondrial membrane. Studied for mitochondrial dysfunction.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Sep 19, 2026.
FOXO4-DRI
SS-31
$44.99
Starting from
$35.00
$16.95
Avg. price per mg
$6.43
28
Vendors selling it
28
23 options
In stock now
32 options
9.0/10
Top trust score
9.1/10
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.