Mazdutide vs Semaglutide
Which should you choose? Here's what you need to know.
The short answer
Mazdutide actually beat semaglutide in a head-to-head trial by adding a glucagon receptor component. But semaglutide is FDA-approved with far more real-world data.
On 20 Sep 2026 Peptide Compare tracked 11 vendors selling Mazdutide, cheapest in stock $7.00 per mg at Eros Peptides, and 32 selling Semaglutide, cheapest $1.50 per mg at Step One.
Mazdutide
Weight Loss (GLP-1)Mazdutide is a GLP-1/glucagon dual agonist that outperformed semaglutide in the head-to-head DREAMS-3 trial — 48% of patients hit both blood sugar and weight loss targets vs 21% on semaglutide.
Choose Mazdutide if:
You want a dual agonist that showed superiority over semaglutide in trials, and you have access to it through international channels.
Semaglutide
Weight Loss (GLP-1)Semaglutide is the most widely used GLP-1 agonist worldwide with FDA approval, years of safety data, and proven cardiovascular benefits in the SELECT trial.
Choose Semaglutide if:
You want the most proven, widely available, FDA-approved option with the longest safety track record.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Sep 20, 2026.
Mazdutide
Semaglutide
$34.99
Starting from
$20.00
$15.28
Avg. price per mg
$24.82
11
Vendors selling it
32
9 options
In stock now
61 options
7.6/10
Top trust score
8.7/10
Ready to buy?
Our top-rated vendor for each, based on trust scores, purity testing, and price.
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.