Retatrutide vs Semaglutide
Which should you choose? Here's what you need to know.
The short answer
Retatrutide is a next-generation triple agonist (GLP-1/GIP/glucagon) showing dramatic weight loss in trials. Semaglutide is the proven, FDA-approved standard.
Retatrutide
Weight Loss (GLP-1)Retatrutide hits three receptors instead of one, and early Phase 2 trials showed up to 24% body weight loss. It's not yet FDA-approved but is the most talked-about next-gen option.
Choose Retatrutide if:
You want to be on the cutting edge and are comfortable with a peptide still in clinical trials.
Semaglutide
Weight Loss (GLP-1)Semaglutide is the gold standard GLP-1 with full FDA approval, extensive safety data, and billions of doses administered worldwide.
Choose Semaglutide if:
You prefer a proven, FDA-approved option with years of real-world safety data.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options.
Ready to buy?
Our top-rated vendor for each, based on trust scores, purity testing, and price.
Best Retatrutide Vendor
$165.00(50mg)
Best Semaglutide Vendor
$50.00(35mg)
Where does this data come from?
We check vendor prices every day and pull in real purity test results from independent labs — not vendor claims. No vendor can pay to rank higher. See our full methodology.