Semaglutide vs Tirzepatide
Which should you choose? Here's what you need to know.
The short answer
Tirzepatide targets two receptors (GIP + GLP-1) and has shown slightly more weight loss in trials. Semaglutide is more established with longer real-world data.
On 9 Oct 2026 Peptide Compare tracked 29 vendors selling Semaglutide, cheapest in stock $1.83 per mg at Modern Research, and 30 selling Tirzepatide, cheapest $1.76 per mg at Modern Research.
Semaglutide
Weight Loss (GLP-1)Semaglutide is the active ingredient in Ozempic and Wegovy. It's a single GLP-1 receptor agonist with years of clinical data and FDA approval for both diabetes and weight loss.
Choose Semaglutide if:
You want a well-established option with the most real-world data, or your provider is more familiar with GLP-1 dosing protocols.
Tirzepatide
Weight Loss (GLP-1)Tirzepatide (Mounjaro/Zepbound) is a newer dual-action peptide hitting both GIP and GLP-1 receptors. Clinical trials showed up to 22.5% body weight reduction.
Choose Tirzepatide if:
You want the latest generation with potentially greater weight loss, or you haven't responded well to GLP-1-only options.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Oct 9, 2026.
Semaglutide
Tirzepatide
$24.99
Starting from
$30.95
$25.64
Avg. price per mg
$9.04
29
Vendors selling it
30
59 options
In stock now
100 options
8.7/10
Top trust score
9.0/10
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.