PE 22-28 vs Semax
Which should you choose? Here's what you need to know.
The short answer
PE 22-28 and Semax are both cognitive / neuro peptides, but they work differently. A synthetic peptide derived from ACTH (4-10) developed in Russia as a nootropic and neuroprotective agent. Available as a prescription nasal spray in Russia. Compare vendor pricing and availability below.
On 9 Oct 2026 Peptide Compare tracked 20 vendors selling PE 22-28, cheapest in stock $3.46 per mg at Polaris Peptides, and 58 selling Semax, cheapest $2.12 per mg at Biotech Peptides.
PE 22-28
Cognitive / NeuroSemax
Cognitive / NeuroA synthetic peptide derived from ACTH (4-10) developed in Russia as a nootropic and neuroprotective agent. Available as a prescription nasal spray in Russia.
Price & availability
Once you've decided which peptide fits your needs, here's how they compare on price and vendor options. Prices verified Oct 9, 2026.
PE 22-28
Semax
$39.99
Starting from
$20.00
$6.22
Avg. price per mg
$11.50
20
Vendors selling it
58
18 options
In stock now
60 options
8.7/10
Top trust score
9.1/10
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Where does this data come from?
We re-check vendor prices continuously and score vendors on Finnrick blind-test results — samples bought anonymously and sent to a lab, not vendor claims. No vendor can pay to rank higher. See our full methodology.